T1/T17 drive Dupilumab-induced eye inflammation

Novel effective eczema drug dupilumab (IL4/IL13 blockade) can induce toxicity resulting in severe uveitis. In this collaborative study we demonstrate with multiplex IMC analysis of eye tissue that this toxic response is driven by T1/T17 inflammation. Published in Allergy last week! We thank Daphne Bakker, Femke van Wijk for a fruitful and exciting collaboration.

Bakker et al., Allergy 2021